Center for Tropical Clinical Pharmacology and Therapeutics (CTCPT)
The Center for Tropical Clinical Pharmacology and Therapeutics (CTCPT) is a research and clinical department of the University of Ghana School of Medicine and Dentistry (UGSMD). The Center conducts multidisciplinary research and training in all aspects of clinical pharmacology. The current research activities of the center are based on clinical studies, employing a range of pharmacometric, pharmacogenetic, pharmacoepidemiologic and laboratory investigations to improve drug therapy of communicable as well as non-communicable diseases. Research at CTCPT are in the following areas;

Malaria Chemotherapy Research

• Clinical trials and in vivo/ in vitro antimalarial drug efficacy testing.
• Pharmacokinetics and Pharmacodynamics of antimalarials in children with HIV or sickle cell disease.
• Malaria Transmission assessment in a potential site for clinical trials.

HIV Research

• Demographic, clinical and genetic risk factors for nevirapine hypersensitivity reactions in HIV-infected patients.
• Post-exposure prophylaxis in health care workers in Korle-Bu Teaching Hospital/ Factors associated with regimen switch in HIV positive patients attending Korle-bu Teaching Hospital (KBTH)
• Putative protective effects of sulphamethoxazole-trimethoprim prophylaxis on malaria incidence in HIV infected children.

Pharmacovigilance Research
The CTCPT is involved in the INDEPTH Network Effectiveness and Safety (INESS) studies which is funded by the Bill and Melinda Gates Foundation and led by the School of Public Health, UG. The WHO Collaborating Center based at the CTCPT is leading Africa-wide efforts to deploy electronic health records for drug and vaccine safety monitoring. Pharmacovigilance activities also include cohort event monitoring of antiretrovirals and pharmaco-epidemiological studies on medicines and vaccines in multiple sites and countries in Africa. The WHO Collaborating Center is especially focused on research on communication in drug safety and the development and deployment of enterprise-wide risk management systems in health care delivery.

Drug Therapy in Special Patient Population Research

• Neonatal drug Therapy research. Interactions between anmikacin and aminophylline in newborns with sepsis.
• Dietetic drug therapy in pregnancy research. Metformin versus insulin in the management of gestational diabetes mellitus and type II pre-gestational diabetes mellitus at Korle Bu Teaching Hospital.

Malnutrition Research

• Role of selected health and social determinants of malnutrition and audit ofinterventions to reduce the condition in moderately and severely malnourished children